منابع مشابه
Protein Folding: Simple Models
Doublié, S., Sawaya, M.R., and Ellenberger, T. (1999). Struct. Fold. son and Beese, 2004). The same mispair, on the other Des. 7, R31–R35. hand, is poorly extended by Dpo4: it was shown to form Echols, H., and Goodman, M.F. (1991). Annu. Rev. Biochem. 60, a reverse wobble, which misaligns the 3 -end of the 477–511. primer and therefore precludes nucleophilic attack (TrinHatahet, Z., Zhou, M., R...
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Over the past 25 years, enormous breakthroughs have been made in understanding protein folding mechanisms. We have now reached an exciting stage, with consensuses beginning to emerge that combine both theoretical and experimental approaches. In addition, new fields have emerged and burgeoned, including in vivo folding and the study of protein misfolding diseases. In today's post-genomic world, ...
متن کاملSimple Models of Protein Folding
Lattice models with simplified interaction potentials have been used to analyze the ability of certain amino acid sequences to adopt a unique configuration in space [1, 2, 3]. Furthermore, phenomenological models have been used to predict protein folding kinetics amongst a subset of energetically favorable states [4, 5]. In the following, I will specifically discuss both the use of two dimensio...
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Most reactions in cells are carried out by enzymes [1]. In many instances the rates of enzyme-catalyzed reactions are enhanced by million fold. A significantly large fraction of all known enzymes are proteins which are made from twenty naturally occurring amino acids. The amino acids are linked by peptide bonds to form polypeptide chains. The primary sequence of a protein specifies the linear o...
متن کاملSimple Models of the Protein Folding Problem
The protein folding problem has attracted an increasing attention from physicists. The problem has a avor of statistical mechanics, but possesses the most common feature of most biological problems – the profound e ects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called “designability principle”. The designability of a structure...
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ژورنال
عنوان ژورنال: Nature
سال: 1974
ISSN: 0028-0836,1476-4687
DOI: 10.1038/249409a0